We recommend that all female pets that are not being used for the specific purpose of breeding and selling pets have ovariohysterectomy performed as soon as it is safely possible, (around 5 months – before first heat or possible accidental pregnancy). Females who have ovariohysterectomy (spay) before their first heat are virtually protected from contracting or dying from ovarian cancer, uterine cancer, mammary cancer, pyometra, dystocia, etc.